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Cal study could be a weakness of this analysis, the strength derived from the direct comparison should also be acknowledged. Furthermore, the trial considered is the only one comparing flexible doses of pregabalin and venlafaxine XR, which is a more appropriate approach than assuming fixed doses. The placebo-adjusted effect size of pregabalin in this trial is similar to the effect estimated in oth
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I.e., it is both cheaper and more efficacious. To our knowledge, there are only three economic studies comparing pregabalin to venlafaxine XR [8,9,33]. NICE [8] performed an economic evaluation based on a network meta-analysis in which the probability of discontinuation due to serious adverse events and the probability of response in patients without those adverse events were estimated. Pregabalin
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